Monday, March 11th, 11h30, Room 454 A, Condorcet Building.

Abdou Rachid Thiam

Biological Emulsions Research Group
Laboratoire de physique de l’ENS
Ecole Normale Supérieure, PSL, Paris

Condensation of Neutral Lipids within the Endoplasmic Reticulum Membrane

Neutral lipids serve as storage molecules within cells, providing a means to buffer fluctuations in lipid and energy. These lipids are synthesized and delivered to the endoplasmic reticulum (ER) through various enzymatic pathways. Due to their hydrophobic nature, neutral lipids tend to accumulate between the bilayer leaflets of the ER membrane. When they reach a critical concentration these neutral lipids condense to form nascent droplets within the membrane which subsequently grow and bud off to form lipid droplet organelles. The processes of condensation and growth known as nucleation and growth respectively are facilitated by specific proteins, lipids, and membrane properties. Disruptions in neutral lipid and lipid droplet biology are associated with numerous cellular dysfunctions which can lead to severe disorders. In my talk, I will discuss our latest research focusing on the mechanisms that control the nucleation and growth steps of lipid droplets.

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