Richard Amedzrovi Agbesi’s PhD thesis defense will take place on Friday, January 19th at 2:00 PM in the Pierre Gilles de Gennes Amphitheater.This thesis, supervised by Nicolas Chevalier and Vincent Fleury, focuses on the Fundamentals of intestinal peristalsis: myogenic, neurogenic, and hydrodynamic behavior. There will be a cocktail session on the 6th floor where some Ghanaian delicacies will be served.
Examining the enteric nervous system, both spontaneous and pinch-induced calcium activity were observed. Utilizing a transgenic line expressing the GCamp6f reporter in neural crest cell derivatives, the spontaneous calcium activity in embryonic mice was studied. Pinching the enteric nervous system using a fine Pasteur pipette triggered a calcium flash. Certain channels crucial for spontaneous activity were identified, and the ’plasticity’ of the mechanosensitive response of the ENS was explored using pharmacological drugs. To assess how pressure gradients influence smooth muscle contractility at the organ level, an in-house hydrostatic pressure model was implemented. Experimental and numerical models were then employed to investigate the role of different gut wave patterns and the associated hydrodynamics in modulating smooth muscle contractility.